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Gastroenterology
Clinical significance of radiation-induced liver disease after stereotactic body radiation therapy for hepatocellular carcinoma
Baek Gyu Jun, Young Don Kim, Gab Jin Cheon, Eun Seog Kim, Eunjin Jwa, Sang Gyune Kim, Young Seok Kim, Boo Sung Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Hong Soo Kim
Korean J Intern Med. 2018;33(6):1093-1102. Published online August 28, 2017
Background/Aims: The aim of this study was to investigate parameters that predict radiation-induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC) and to identify the clinical significance of RILD.
Methods: We retrospectively rev..
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Hemato-oncology
Third-party regulatory T cells prevent murine acute graft-versus-host disease
Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho
Korean J Intern Med. 2018;33(5):980-989. Published online October 19, 2017
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used ..
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Pulmonology
Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease
Chi Young Jung, Yeoung Hun Choe, Sang Yeub Lee, Woo Jin Kim, Jong Deog Lee, Seung Won Ra, Eu Gene Choi, Jae Seung Lee, Myung Jae Park, Ju Ock Na
Korean J Intern Med. 2018;33(5):941-951. Published online June 25, 2018
Background/Aims: To use serological and multiplex polymerase chain reaction (PCR) assays to examine sputum samples from patients experiencing acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for the presence of atypical pathogens, including Mycoplasma pneumoniae, Chlamydia pneumo..
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Gastroenterology
Disparity in Crohn’s disease activity between home and clinics is associated with unscheduled hospital visits due to disease flares
Eun Soo Kim, Yoo Jin Lee, Byung Ik Jang, Kyeong Ok Kim, Eun Young Kim, Hyun Seok Lee, Seong Woo Jeon, Sang Gyu Kwak; on behalf of Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Korean J Intern Med. 2018;33(5):902-910. Published online January 17, 2018
Background/Aims: E-health technologies have been implemented for the management of Crohn’s disease (CD). We aimed to identify differences between patient activities at home and at routine clinic visits using a web-based self-reporting CD symptom diary (CDSD) and to determine the impact of this dis..
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Cardiology
Percutaneous coronary intervention in patients with multi-vessel coronary artery disease: a focus on physiology
Yun-Kyeong Cho, Chang-Wook Nam
Korean J Intern Med. 2018;33(5):851-859. Published online March 21, 2018
Multi-vessel coronary artery disease (MVD) frequently features ambiguous or intermediate lesions that may be both serial and complex, suggesting that multiple regions require revascularization. Percutaneous coronary intervention (PCI) is associated with various challenges such as appropriate identif..
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Gastroenterology
Immunoglobulin G4-related sclerosing cholangitis
George Goodchild, Stephen P. Pereira, George Webster
Korean J Intern Med. 2018;33(5):841-850. Published online July 27, 2018
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition of which IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation. In this review, we provide an overview of IgG4-RD, with a focus on the biliary manifestations. In particular, we describe the imp..
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Pulmonology
Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease
Woo Ho Ban, Hyeon Hui Kang, In Kyoung Kim, Jick Hwan Ha, Hyonsoo Joo, Jong Min Lee, Jeong Uk Lim, Sang Haak Lee, Chin Kook Rhee
Korean J Intern Med. 2018;33(4):745-752. Published online March 13, 2018
Background/Aims: Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD stat..
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Cardiology
Use of hypnotics and the risk of or mortality from heart disease: a meta-analysis of observational studies
Young-Hyo Kim, Hong-Bae Kim, Do-Hyoung Kim, Ja-Young Kim, Hyun-Young Shin
Korean J Intern Med. 2018;33(4):727-736. Published online August 28, 2017
Background/Aims: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using a meta-analysis of available literatures.
Methods: We searched t..
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Rheumatology
Baseline extent of damage predicts spinal radiographic progression in Korean patients with ankylosing spondylitis treated with golimumab
Jeong Seok Lee, Yeong Wook Song, Tae Hwan Kim, Won Tae Chung, Seung Geun Lee, Sung Hwan Park, Gwan Gyu Song, Dae Young Yu, Stephen Xu, Eun Young Lee
Korean J Intern Med. 2018;33(3):622-628. Published online January 20, 2017
Background/Aims: For patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristi..
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Atorvastatin inhibits osteoclast differentiation by suppressing NF-κB and MAPK signaling during IL-1β-induced osteoclastogenesis
Won-Seok Lee, Eun-Gyeong Lee, Myung-Soon Sung, Yun-Jung Choi, Wan-Hee Yoo
Korean J Intern Med. 2018;33(2):397-406. Published online March 28, 2017
Background/Aims: To define the effect of statins on interleukin 1β (IL-1β)-induced osteoclastogenesis and elucidate the underlying mechanisms.
Methods: Bone marrow cells were obtained from 5-week-old male ICR (Institute for Cancer Research) mice, and they were cultured to differentiate them into ..
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Endocrinology-metabolism
Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats
Yoo-Cheol Hwang, Da-Hee Oh, Moon Chan Choi, Sang Yeoul Lee, Kyu-Jeong Ahn, Ho-Yeon Chung, Sung-Jig Lim, Sung Hyun Chung, In-Kyung Jeong
Korean J Intern Med. 2018;33(2):347-355. Published online February 1, 2017
Background/Aims: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the molecular mechanism of the antidiabetic effects in the liver have not been elu..
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Rheumatology
New insights into the role of renal resident cells in the pathogenesis of lupus nephritis
Seung-Ki Kwok, George C. Tsokos
Korean J Intern Med. 2018;33(2):284-289. Published online January 12, 2018
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SL..
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Infectious diseases
Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea
Sung-Yeon Cho, Hyeon-Jeong Lee, Dong-Gun Lee
Korean J Intern Med. 2018;33(2):256-276. Published online February 27, 2018
Hematopoietic stem cell transplantation (HSCT) is a treatment for hematologic malignancies, immune deficiencies, or genetic diseases, ect. Recently, the number of HSCTs performed in Korea has increased and the outcomes have improved. However, infectious complications account for most of the morbidit..
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Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea
Myoung-don Oh, Wan Beom Park, Sang-Won Park, Pyoeng Gyun Choe, Ji Hwan Bang, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Nam Joong Kim
Korean J Intern Med. 2018;33(2):233-246. Published online February 27, 2018
Middle East Respiratory Syndrome coronavirus (MERS-CoV) was first isolated from a patient with severe pneumonia in 2012. The 2015 Korea outbreak of MERSCoV involved 186 cases, including 38 fatalities. A total of 83% of transmission events were due to five superspreaders, and 44% of the 186 MERS case..
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Pulmonology
Factors associated with low-level physical activity in elderly patients with chronic obstructive pulmonary disease
Sang Hee Lee, Ki Uk Kim, Haejung Lee, Yun Seong Kim, Min Ki Lee, Hye-Kyung Park
Korean J Intern Med. 2018;33(1):130-137. Published online June 7, 2017
Background/Aims: In patients with chronic obstructive pulmonary disease (COPD), the extent of physical activity (PA) is correlated with disease severity and prognosis. However, factors associated with low-level PA in elderly COPD patients are not known. We assessed the levels of PA and clinical fact..
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Gastroenterology
Changing treatment paradigms for the management of inflammatory bowel disease
Jong Pil Im, Byong Duk Ye, You Sun Kim, Joo Sung Kim
Korean J Intern Med. 2018;33(1):28-35. Published online December 28, 2017
Inf lammatory bowel disease (IBD) is a chronic and progressive inf lammatory condition of the gastrointestinal tract causing bowel damage, hospitalizations, surgeries, and disability. Although there has been much progress in the management of IBD with established and evolving therapies, most current..
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Novel treatments for inflammatory bowel disease
Hyo Sun Lee, Soo-Kyung Park, Dong Il Park
Korean J Intern Med. 2018;33(1):20-27. Published online December 11, 2017
Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of treatment options aimed at a variety of pathological mechanisms offers new hope for customized therapies..
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Updated treatment strategies for intestinal Behçet’s disease
Yong Eun Park, Jae Hee Cheon
Korean J Intern Med. 2018;33(1):1-19. Published online December 8, 2017
Behçet’s disease (BD) is a chronic, idiopathic, relapsing immune-mediated disease involving multiple organs, and is characterized by recurrent oral and genital ulcers, ocular disease, gastrointestinal ulcers, vascular diseases, and skin lesions. In particular, gastrointestinal involvement in BD i..
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Multiple giant calcified aneurysms of three coronary arteries
Hyukjin Park, Young Joon Hong, Young Keun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Korean J Intern Med. 2017;32(6):1101-1103. Published online October 17, 2017
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Rheumatology
The role of 18F-fluorodeoxyglucose positron emission tomography in the assessment of disease activity of adult-onset Still’s disease
Young-Sil An, Chang-Hee Suh, Ju-Yang Jung, Hundo Cho, Hyoun-Ah Kim
Korean J Intern Med. 2017;32(6):1082-1089. Published online December 7, 2016
Background/Aims: 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has been suggested as a reliable imaging technique for monitoring of disease activity in patients with adult-onset Still’s disease (AOSD). Therefore, we investigated the ..
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